Inhibition of alcohol dehydrogenase by dimethyl formamide and dimethyl sulfoxide
1979; Elsevier BV; Volume: 4; Issue: 6 Linguagem: Inglês
10.1016/0378-4274(79)90117-6
ISSN1879-3169
Autores Tópico(s)Eicosanoids and Hypertension Pharmacology
ResumoDimethyl formamide (DMF) and dimethyl sulfoxide (DMSO) inhibit mouse liver alcohol dehydrogenase (LADH) in vitro. The inhibition is “uncompetitive” with both DMF and DMSO, where both Km and Vmax were changed in the presence of the inhibitor. Both DMF and DMSO prolonged significantly ethanol-induced loss of righting reflex in mice, but not barbital-induced loss of righting reflex.
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