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Treatment of Psoriasis With Topically Applied Tretinoin and Steroid Ointment

1975; American Medical Association; Volume: 111; Issue: 8 Linguagem: Inglês

10.1001/archderm.1975.01630200061006

1538-3652

Kays H. Kaidbey,

Pharmaceutical studies and practices

The sequential application of tretinoin and a corticosteroid ointment was considerably more effective in the treatment of plaque-type psoriasis than either drug alone in a pilot study. The best results were obtained with 0.3% tretinoin followed by a potent corticosteroid ointment. Combined therapy was particularly efficacious in steroid-resistant psoriasis, including that on the palms, elbows, and knees. Irritancy from the high-strength tretinoin was a potentially troublesome side-effect. Care must be taken to avoid drug contact on areas that are easily irritated.