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Classical and novel directions in neurotrophin transport and research: Anterograde transport of brain-derived neurotrophic factor by sensory neurons

1999; Wiley; Volume: 45; Issue: 4-5 Linguagem: Inglês

10.1002/(sici)1097-0029(19990515/01)45

1097-0029

James R. Tonra,

Receptor Mechanisms and Signaling

Microscopy Research and TechniqueVolume 45, Issue 4-5 p. 225-232 Topical PaperFree Access Classical and novel directions in neurotrophin transport and research: Anterograde transport of brain-derived neurotrophic factor by sensory neurons James R. Tonra, Corresponding Author James R. Tonra Millennium BioTherapeutics, Cambridge, MassachusettsMillennium BioTherapeutics, 620 Memorial Drive, Cambridge, MA 02139.Search for more papers by this author James R. Tonra, Corresponding Author James R. Tonra Millennium BioTherapeutics, Cambridge, MassachusettsMillennium BioTherapeutics, 620 Memorial Drive, Cambridge, MA 02139.Search for more papers by this author First published: 11 June 1999 https://doi.org/10.1002/(SICI)1097-0029(19990515/01)45:4/5 3.0.CO;2-1Citations: 25AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract After the discovery of nerve growth factor, a classic model of neurotrophin action was developed. In this model, nerve endings compete for limited quantities of neurotrophic factors produced in neuronal target tissues. Neurotrophins are bound with high-affinity receptors expressed on the neuronal membrane and then endocytosed and retrogradely transported back to the cell body of responsive neurons. This classic model of target derived trophic support has been utilized to explain a wide range of trophic actions including effects on neuronal survival, terminal branching, and protein expression. However, a number of recent findings in the field of neurotrophin research cannot be explained using the classic model. In the peripheral nervous system (PNS), sensory neurons have been shown to contain mRNA for a member of the neurotrophin family, brain-derived neurotrophic factor (BDNF). Sensory neurons do not receive synaptic input so neurotrophin production by these cells does not fit into the classic target derived model. In contrast to target derived trophic support, BDNF produced by sensory neurons provides local autocrine and paracrine neurotrophic support in vitro. 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