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Variation of serum creatine kinase (CK) levels and prevalence of persistent hyperCKemia in a Norwegian normal population. The Tromsø Study

2011; Elsevier BV; Volume: 21; Issue: 7 Linguagem: Inglês

10.1016/j.nmd.2011.04.007

1873-2364

Hallvard Lilleng, Karin Abeler, Stein Harald Johnsen, Eva Stensland, Sissel Løseth, Rolf Jorde, Yngve Figenschau, Sigurd Lindal, Tom Wilsgaard, Svein Ivar Bekkelund,

Genetic Neurodegenerative Diseases

In this cross-sectional study we assessed the prevalence of hyperCKemia, defined as persistent CK values ≥210 U/L in women, ≥400 U/L in men <50 years and ≥280 U/L in men ≥50 years (reference values according to the Nordic Reference Interval Project). Blood samples were obtained from 12,828 participants in the 6th survey of The Tromsø Study. We identified 686 (5.3%) individuals with incidentally elevated CK. After a standardized control test, 169 persons (1.3%) had persistent hyperCKemia, i.e. 69.9% normalization. Use of statins or other causes of hyperCKemia were detected in 78 individuals (46.2%), giving a prevalence of "idiopathic hyperCKemia" of 0.71%. CK variation was highest in younger men and in females between 60 and 69 years. This study has identified persistent hyperCKemia in 1.3% of the normal population, and demonstrates the importance of performing controlled CK analyses, also in those with identified risk factors.