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Preparation of conjugated linoleic acid from safflower oil

1999; Wiley; Volume: 76; Issue: 6 Linguagem: Inglês

10.1007/s11746-999-0167-3

1558-9331

David W.L., Antoni A. Wierzbicki, Catherine J. Field, M. Thomas Clandinin,

Aquaculture Nutrition and Growth

Abstract Synthetically prepared mixtures of conjugated linoleic acid (CLA) are widely used in animal and cell culture studies to investigate the potential effects of the Δ9 c , 11 t ‐18:2 isomer found in food products from ruminant animals. Alkali isomerization of linoleic acid is a common method used in the synthesis of a mixture of CLA isomers containing predominantly the Δ9 c , 11 t ‐18:2 and Δ10 t , 12 c ‐18:2 isomers. Some biological activity might also be mediated by the Δ10 t , 12 c ‐18:2 isomer. Currently few published methodologies exist describing procedures for the enrichment of these two isomers. A method is described herein to take advantage of an inexpensive oil, safflower oil, for use in synthesis of CLA and a procedure to enrich the Δ10 t , 12 c ‐18:2 isomer.