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Screening of Formulation Variables for the Preparation of Poly(<I>ε</I>-caprolactone) Nanocapsules Containing the Local Anesthetic Benzocaine

2011; American Scientific Publishers; Volume: 11; Issue: 3 Linguagem: Inglês

10.1166/jnn.2011.3547

ISSN

1533-4899

Autores

Carolina Morales Moraes, Angélica Prado de Matos, Renato Grillo, Nathalie Ferreira Silva de Melo, Eneida de Paula, Newton Luiz Dias Filho, André Henrique Rosa, Leonardo Fernandes Fraceto,

Tópico(s)

Innovative Microfluidic and Catalytic Techniques Innovation

Resumo

In this work we describe the screening of four parameters in the preparation, by nanoprecipitation, of poly(epsilon-caprolactone) nanocapsules, used as a drug carrier system for the local anesthetic, benzocaine. A 2(4-1) factorial experimental design was used to study the influence of four different independent variables (polymer, oily phase, Span 60 and Tween 80) on nanocapsule characteristics (size, polydispersion index, zeta potential) and drug loading capability. Best results were obtained using an aqueous formulation comprising 100 mg of polymer, 200 mg of oily phase, 40 mg of Span 60 and 60 mg of Tween 80 in a final volume of 10 mL which produced a colloidal system with particle size of 188 nm, zeta potential -32 mV, polydispersion index 0.07, and benzocaine association efficiency > 87%. These findings open the way for future clinical studies using such formulations.

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