β‐Carbonylamides in peptide chemistry. I. Optical rotatory properties of N ‐acetoacetyl amino acids
1971; Wiley; Volume: 10; Issue: 11 Linguagem: Inglês
10.1002/bip.360101119
ISSN1097-0282
AutoresClaudio Toniolo, Fernando Filira, Carlo Di Bello,
Tópico(s)DNA and Nucleic Acid Chemistry
ResumoAbstract The Cotton effects of N ‐acetoacetyl amino acids and derivatives were examined by a circular dichroism technique. A correlation has been established between the sign of the Cotton effect and the absolute configuration of the asymmetric center. The L derivatives show, in dioxane, negative circular dichroism curves, whereas the D antipodes present positive curves. The effect of solvent and pH and influence of alkylation at the amide nitrogen are also discussed.
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