Artigo Revisado por pares

INHIBITION OF HERPESVIRUS DNA SYNTHESIS BY 9‐β‐D‐ARABINOFURANOSYLADENINE IN CELLULAR AND CELL‐FREE SYSTEMS *

1977; Wiley; Volume: 284; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1977.tb21935.x

ISSN

1749-6632

Autores

Wernér E.G. Müller, Rudolf K. Ζahn, K. Bittlingmaier, D. Falke,

Tópico(s)

Fungal Plant Pathogen Control

Resumo

Annals of the New York Academy of SciencesVolume 284, Issue 1 p. 34-48 INHIBITION OF HERPESVIRUS DNA SYNTHESIS BY 9-β-D-ARABINOFURANOSYLADENINE IN CELLULAR AND CELL-FREE SYSTEMS * W. E. G. Müller, W. E. G. Müller Institut für Physiologische Chemie and Institut für Medizinische Mikrobiologie Johannes Gutenberg-Universität 65 Mainz Johann Joachim Becher Weg 13, West GermanySearch for more papers by this authorR. K. Zahn, R. K. Zahn Institut für Physiologische Chemie and Institut für Medizinische Mikrobiologie Johannes Gutenberg-Universität 65 Mainz Johann Joachim Becher Weg 13, West GermanySearch for more papers by this authorK. Bittlingmaier, K. Bittlingmaier Institut für Physiologische Chemie and Institut für Medizinische Mikrobiologie Johannes Gutenberg-Universität 65 Mainz Johann Joachim Becher Weg 13, West GermanySearch for more papers by this authorD. Falke, D. Falke Institut für Physiologische Chemie and Institut für Medizinische Mikrobiologie Johannes Gutenberg-Universität 65 Mainz Johann Joachim Becher Weg 13, West GermanySearch for more papers by this author W. E. G. Müller, W. E. G. Müller Institut für Physiologische Chemie and Institut für Medizinische Mikrobiologie Johannes Gutenberg-Universität 65 Mainz Johann Joachim Becher Weg 13, West GermanySearch for more papers by this authorR. K. Zahn, R. K. Zahn Institut für Physiologische Chemie and Institut für Medizinische Mikrobiologie Johannes Gutenberg-Universität 65 Mainz Johann Joachim Becher Weg 13, West GermanySearch for more papers by this authorK. Bittlingmaier, K. Bittlingmaier Institut für Physiologische Chemie and Institut für Medizinische Mikrobiologie Johannes Gutenberg-Universität 65 Mainz Johann Joachim Becher Weg 13, West GermanySearch for more papers by this authorD. Falke, D. Falke Institut für Physiologische Chemie and Institut für Medizinische Mikrobiologie Johannes Gutenberg-Universität 65 Mainz Johann Joachim Becher Weg 13, West GermanySearch for more papers by this author First published: May 1977 https://doi.org/10.1111/j.1749-6632.1977.tb21935.xCitations: 93 * This work was partially undertaken during the tenure of a Yamagiwa-Yoshida Memorial International Cancer Study Grant awarded to W.E.G.M. by the International Union Against Cancer, during a sabbatical leave in the Department of Biochemistry (Prof. F. J. Bollum), Albert B. Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40506. Additionally, the work was supported by a grant from the Commission for Educational Exchange between the Federal Republic of Germany and the United States of America (Fulbright Commission). AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Lee, W. W., A. Benitez, L. Goodman & B. R. Baker. 1960. Potential anticancer agents. XL. Synthesis of the β-anomer of 9-(D-arabinofuranosyl) adenine. J. Amer. Chem. Soc. 82: 2648–2649. 2 Anderson, M. M. & R. J. Suhadolnik. 1973. Enzymatic epimerization of the 2′-hydroxyl group of adenosine in the biosynthesis of 9-β-D-arabinofuranosyladenine by Streptomyces antibioticus. In IUB-Ninth International Congress of Biochemistry, Abstract Book 3r10. Aktiebolaget Egnellska Boktryckeriet. Stockholm, Sweden. 3 Cohen, S. S. 1966. Introduction to the biochemistry of D-arabinosyl nucleosides. Prog. Nucleic Acid Res. Mol. Biol. 5: 1–88. 4 Privat de Garilhe, M. & J. de Rudder. 1964. Effect de deux nucléosides de l'arabinose sur la multiplication des virus de l'herpès et de la vaccine en culture cellulaire. C. R. Acad. Sci. 259: 2725–2728. 5 Freeman, G., A. Kühn & I. Sultanian. 1965. Tumorigenic virus and cell responses to biologically active compounds. II. Pharmacologic specificity in cell-virus relationship. Ann. N. Y. Acad. Sci., 130: 330–342. 6 Sidwell, R. W., G. Arnett & G. J. Dixon. 1967. Effect of selected biologically active compounds on in vitro cytomegalovirus (CMV) infections. In Abstracts of Papers, 7th Intersci. Conf. Antimicr. Agents and Chemotherapy. Abst. No. 64: 28–29. Chicago . 7 Sidwell, R. W., G. J. Dixon, S. M. Sellers & F. M. Schabel. 1968. In vivo antiviral properties of biologically active compounds. II. Studies with influenza and vaccinia viruses. Appl. Microbiol. 16: 370–392. 8 Sidwell, R. W., G. J. Dixon, F. M. Schabel & D. H. Kaump. 1968. Antiviral activity of 9-β-D-arabinofuranosyladenine. II. Activity against herpes simplex keratitis in hamsters. Antimicr. Agents and Chemotherapy: 148–154. 9 Ortiz, P. J., M. J. Manduka & S. S. Cohen. 1972. The lethality of some D-arabinosyl nucleotides to mouse fibroblasts. Cancer Res. 32: 1512–1517. 10 Plunkett, W., L. Lapi, P. J. Ortiz & S. S. Cohen. 1974. Penetration of mouse fibroblasts by the 5′-phosphate of 9-β-D-arabinofuranosyladenine and incorporation of the nucleotide into DNA. Proc. Nat. Acad. Sci. U.S.A. 71: 73–77. 11 Plunkett, W. & S. S. Cohen. 1975. Metabolism of 9-β-D-arabino-furanosyladenine by mouse fibroblasts. Cancer Res. 35: 415–422. 12 Brink, J. J. & G. A. Le Page. 1965. 9-β-D-arabinofuranosyladenine as an inhibitor of metabolism in normal and neoplastic cells. Can. J. Biochem. 43: 1–15. 13 Müller, W. E. G., H. J. Rohde, R. Beyer, A. Maidhof, M. Lachmann, H. Taschner & R. K. Zahn. 1975. Mode of action of 9-β-D-arabinofuranosyladenine on the synthesis of DNA, RNA, and protein in vivo and in vitro. Cancer Res. 35: 2160–2168. 14 Moore, E. C. & S. S. Cohen. 1967. Effects of arabinonucleotides on ribonucleotide reduction by an enzyme system from rat tumor. J. Biol. Chem. 242: 2116–2118. 15 Furth, J. J. & S. S. Cohen. 1967. Inhibition of mammalian DNA polymerase by the 5′-triphosphate of 9-β-D-arabinofuranosyladenine. Cancer Res. 27: 1528–1533. 16 Ortiz, P. J. 1972. The inhibition of E. coli adenyl cyclase by ara ATP. Biochem. Biophys. Res. Commun. 46: 1728–1733. 17 Shipman, C. & J. C. Drach. 1974. Effect of arabinosyladenine on cellular and viral DNA synthesis in herpes simplex virus-infected synchronized KB cells. Abstr. Ann. Mtg. Amer. Soc. Microbiol.: 97. 18 Shannon, W. M. 1975. Adenine arabinoside: Antiviral activity in vitro. In Adenine Arabinoside: An Antiviral Agent. D. Pavan-Langston, R. A. Buchanan and C. A. Alford, Eds.: 1–43. Raven Press. New York , N.Y . 19 Bennett, L. L., W. M. Shannon, P. W. Allan & G. Arnett. Unpublished results. Cited in Ref. 18. 20 Zahn, R. K., E. Tiesler, A. K. Kleinschmidt & D. Lang. 1962. Ein Konservierungs-und Darstellungsverfahren für Desoxyribonucleinsäuren und ihre Ausgangsmaterialien. Biochem. Z. 336: 281–298. 21 Gauchel, D. 1968. Die Synthese von l-β-D-Arabinofuranosylcytosin-5′Triphosphat. Diplomarbeit der naturwissenschaftlichen Fakultät, Mainz, Germany. 22 Falke, D. 1967. Ca++, Histidin und Zn++ als Faktoren bei der Riesenzellbildung durch Herpesvirus hominis. Z. Med. Mikrobiol. Immunol. 153: 175–185. 23 Müller, W. E. G., D. Falke, B. Heicke & R. K. Zahn. 1973. Biological activity of 2-phenylethanol and its derivatives. VIII. Influence on herpesvirus DNA synthesis in rabbit kidney cells. Arch. Ges. Virusforsch. 40: 205–214. 24 Dundaroff, S. & D. Falke. 1972. Thymidine-, uridine- and choline-kinase in rabbit kidney cells infected with herpesvirus hominis, type 1 and 2. Arch. Virusforsch. 38: 56–66. 25 Müller, W. E. G., D. Falke & R. K. Zahn. 1973. DNA-dependent DNA polymerase pattern in noninfected and herpesvirus infected rabbit kidney cells. Arch. ges. Virusforsch. 42: 278–284. 26 Weissbach, A., S. Hong, J. Aucke & R. Muller. 1973. Characterization of Herpes simplex virus-induced deoxyribonucleic acid polymerase. J. Biol. Chem. 248: 6270–6277. 27 Bollum, F. J. 1966. Filter paper disc techniques for assaying radioactive macromolecules. In Procedures in Nucleic Acid Research. G. L. Cantoni & D. R. Davies, Eds.: 284–295. Harper and Row. New York , N.Y . 28 Kaplan, A. S. 1969. Isopycnic banding of viral DNA in cesium chloride. In: Fundamental Techniques in Virology. K. Habel & N. P. Salzman, Eds.: 487–501. Academic Press. New York , N.Y . 29 Graham, I. B., H. Ludwig, D. L. Bronson, M. Benyesh-Melnick & N. Biswol. 1972. Physicochemical properties of the DNA of Herpesvirus. Biochim. Biophys. Acta 259: 13–23. 30 Lowry, O. H., N. J. Rosebrough, A. L. Farr & R. J. Randall. 1951. Protein measurement with the Folin Phenol reagent. J. Biol. Chem. 193: 265–275. 31 Burton, K. 1956. A study of conditions and mechanism of the diphenylamine reaction for colorimetric estimation of deoxyribonucleic acid. Biochem. J. 62: 315–323. 32 Loeb, L. A. 1969. Purification and properties of deoxyribonucleic acid polymerase from nuclei of sea urchin embryos. J. Biol. Chem. 244: 1672–1681. 33 Smith, R. G. & R. C. Gallo. 1972. DNA-dependent DNA polymerase I and II from normal human-blood lymphocytes. Proc. Nat. Acad. Sci. U.S.A. 69: 2879–2884. 34 Müller, W. E. G., Z. Yamazaki, H. H. Sögtrop & R. K. Zahn. 1972. Action of 1-β-D-arabinofuranosylcytosine on mammalian tumor cells. 2. Inhibition of mammalian and oncogenic viral polymerases. Europ. J. Cancer 8: 421–428. 35 Bollum, F. J. 1975. Mammalian DNA polymerases. Prog. Nucleic Acid Res. Mol. Biol. 15: 109–144. 36 Webb, J. L. 1963. Enzyme and Metabolic Inhibitors, Vol. 1: 104–105. Academic Press. New York , N.Y. 37 Keir, H. M., J. Hay, J. M. Morrison & H. Subak-Sharpe. 1966. Altered properties of deoxyribonucleic acid nucleotidyltransferase after infection of mammalian cells with Herpes Simplex Virus. Nature 210: 369–371. 38 Müller, W. E. G., B. Heicke & R. K. Zahn. 1971. Biological activity of β-phenylethanol and its derivatives. V. Influence on DNA and RNA synthesis in different in vitro systems. Biochim. Biophys. Acta 240: 506–514. 39 Wagar, M. A., L. A. Burgoyne & M. R. Atkinson. 1971. Deoxyribonucleic acid synthesis in mammalian nuclei: Incorporation of deoxyribonucleotides and chain-terminating nucleotide analogues. Biochem. J. 121: 803–809. 40 Plunkett, W. & S. S. Cohen. 1975. Two approaches that increase the activity of analogs of adenine nucleosides in animal cells. Cancer Res. 35: 1547–1554. 41 Le Page, G. A. & I. G. Jungov. 1965. Metabolism of purine nucleoside analogs. Cancer Res. 25: 46–52. 42 Lineweaver, H. & D. Burk. 1934. The determination of enzyme dissociation constants. J. Amer. Chem. Soc. 56: 408–412. Citing Literature Volume284, Issue1Third Conference on Antiviral SubstancesMay 1977Pages 34-48 ReferencesRelatedInformation

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