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PNA-encoded chemical libraries

2015; Elsevier BV; Volume: 26; Linguagem: Inglês

10.1016/j.cbpa.2015.01.005

1879-0402

Claudio Zambaldo, Sofía Barluenga, Nicolas Winssinger,

RNA and protein synthesis mechanisms

Peptide nucleic acid (PNA)-encoded chemical libraries along with DNA-encoded libraries have provided a powerful new paradigm for library synthesis and ligand discovery. PNA-encoding stands out for its compatibility with standard solid phase synthesis and the technology has been used to prepare libraries of peptides, heterocycles and glycoconjugates. Different screening formats have now been reported including selection-based and microarray-based methods that have yielded specific ligands against diverse target classes including membrane receptors, lectins and challenging targets such as Hsp70.