Cyclic Voltammetry in a Perfluorocarbon Emulsion Blood Substitute
2007; Wiley; Volume: 19; Issue: 11 Linguagem: Inglês
10.1002/elan.200603830
ISSN1521-4109
AutoresRebecca Barlag, H. Brian Halsall, William R. Heineman,
Tópico(s)Electrochemical sensors and biosensors
ResumoAbstract Cyclic voltammetry in a perfluorocarbon emulsion based blood substitute (PEBS) was evaluated. The intent was to determine how PEBS affects the voltammetry of four representative electroactive compounds: potassium ferricyanide, ruthenium(II) trisbipyridine (rutris), hydroquinone, and 2,6‐dichloroindophenol (DCIP). Voltammograms in 0–20% PEBS‐Tris buffer mixtures are affected by PEBS, but reasonably well‐defined voltammograms are obtained in as much as 20% v/v. This report also shows that PEBS has only a small effect on amperometric detection of the reaction between DCIP and nicotinamide adenine dinucleotide (NADH), which has importance in clinical homogeneous immunoassays. Results support continued exploration of voltammetry/amperometry for quantitative analysis in this medium.
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