FERTILITY AND SEXUAL FUNCTION FOLLOWING ORCHIECTOMY AND 2 CYCLES OF CHEMOTHERAPY FOR STAGE I HIGH RISK NONSEMINOMATOUS GERM CELL CANCER
2001; Lippincott Williams & Wilkins; Volume: 165; Issue: 2 Linguagem: Inglês
10.1097/00005392-200102000-00022
ISSN1527-3792
AutoresDominik Böhlen, Fiona C. Burkhard, Robert Mills, Roland Sonntag, Urs E. Studer,
Tópico(s)Sarcoma Diagnosis and Treatment
ResumoWe investigate fertility and sexual function in patients following orchiectomy and adjuvant cisplatin based chemotherapy for high risk, stage I nonseminomatous germ cell tumor of the testis.Between 1985 and 1994, 59 patients with stage I nonseminomatous germ cell tumor and poor prognostic factors were treated with 2 cycles of cisplatin, vinblastine and bleomycin, or bleomycin, etoposide and cisplatin after orchiectomy. At least 32 months following treatment all patients were contacted and asked to complete a questionnaire regarding fertility and sexual activity, and to volunteer for a semen and hormonal analysis.Of the 59 patients 49 (83%) completed the questionnaire. Before chemotherapy 18 (37%) patients had fathered children, 6 (12%) were involuntarily childless and none had a major sexual dysfunction. After treatment 11 (22%) patients fathered children, and 5 (10%) were involuntarily childless, with 4 involuntarily childless before chemotherapy. There were no significant alterations in sexual function. Semen analysis in 27 patients was normal in 23, and revealed mild oligospermia in 2 and azoospermia in 2. In 18 patients with hormone analysis median values for luteinizing hormone and free testosterone were normal but median value for follicle-stimulating hormone was slightly increased.Two cycles of cisplatin based adjuvant chemotherapy do not seem to affect adversely fertility or sexual activity.
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