Studies on enzymatic dealkylation of D-lysergic acid diethylamide (LSD)
1974; Elsevier BV; Volume: 23; Issue: 6 Linguagem: Inglês
10.1016/0006-2952(74)90007-0
ISSN1873-2968
AutoresTetsukichi Niwaguchi, Takako Inoue, Yuji Nakahara,
Tópico(s)Polyamine Metabolism and Applications
ResumoNew dealkylated metabolites, D-lysergic acid monoethylamide (LAE) and D-N−6-demethyl-lysergic acid diethylamide (norLSD), were formed by incubation of D-lysergic acid diethylamide (LSD) with rat liver 9000 g supernatant fractions. It was elucidated that these dealkylations were mediated by an NADPH and oxygen dependent enzyme in liver microsomes and were inhibited by SKF 525-A. Tranquillizing agents such as chlorpromazine, nitrazepam and meprobamatc, and certain brain monoamines inhibited these enzymatic dealkylations of LSD. Species differences were investigated.
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