Portal de Periódicos da CAPES

Hepatic polyploidy and liver growth control

2000; Elsevier BV; Volume: 10; Issue: 3 Linguagem: Inglês

10.1006/scbi.2000.0317

1096-3650

Sanjeev Gupta,

DNA Repair Mechanisms

The onset of cellular polyploidy is recognized in all differentiated mammalian tissues. Polyploidy has been noted frequently in the normal liver, as well as in pathophysiological states of the liver. As insights into the significance of polyploidy accumulate gradually, it is becoming clear that cells belonging to high ploidy classes exhibit advancement toward terminal differentiation and cellular senescence with greater probabilities of apoptosis. Involvement of specific genetic abnormalities, such as impaired DNA repair, may lead to hepatocellular polyploidy. Working models indicate that extensive polyploidy could lead to organ failure, as well as to oncogenesis with activation of precancerous cell clones.