Spironolactone: A Glucocorticoid Agonist or Antagonist?
1982; Informa; Volume: 4; Issue: 9-10 Linguagem: Inglês
10.3109/10641968209061629
ISSN0730-0077
AutoresThomas J. Campen, Darrell D. Fanestil,
Tópico(s)Hormonal and reproductive studies
ResumoSpironolactone displaces 3H-dexamethasone from HTC cell nuclei and inhibits the induction of tyrosine aminotransferase (TAT) activity by dexamethasone in HTC cells. Spironolactone alone fails to increase TAT activity in HTC cells or in the liver of adrenalectomized rats. These actions indicate that spironolactone lacks glucocorticoid agonist activity but can be an antagonistic to the actions of glucocorticoid as well as mineralocorticoid steroid hormones.
Referência(s)