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Linear motifs: Evolutionary interaction switches

2005; Wiley; Volume: 579; Issue: 15 Linguagem: Inglês

10.1016/j.febslet.2005.04.005

1873-3468

Victor Neduva, Robert B. Russell,

RNA Research and Splicing

Linear motifs are short sequence patterns associated with a particular function. They differ fundamentally from longer, globular protein domains in terms of their binding affinities, evolution and in how they are found experimentally or computationally. In this Minireview, we discuss various aspects of these critically important functional regions.