Portal de Periódicos da CAPES

Estrogen Receptors in Human Pituitary Adenomas*

1980; Oxford University Press; Volume: 51; Issue: 4 Linguagem: Inglês

10.1210/jcem-51-4-897

1945-7197

Marie-France Pichon, D. Bression, F Peillon, Maurice Tubiana,

Angiogenesis and VEGF in Cancer

Estrogen-binding proteins were observed in the cytosol of human pituitary adenomas. The Kd for estradiol was 0.44 nM at 0 C, and hormonal specificity was that expected for estrogen receptors. Sucrose gradient sedimentation experiments revealed that receptors from different tumors existed in either the 8S or the 4S form or both. Of the 23 tumors examined, 14 contained estrogen receptors. Receptors were more often present and their concentration was higher in PRL-secreting adenomas (mean ± SEM, 20.6 ± 13.4 fmol/mg protein; 7 determinations) than in GH-secreting adenomas (1.4 ± 0.8 fmol/mg protein; 9 determinations) and chromophobe tumors (4.1 ±1.6 fmol/mg protein; 7 determinations). There was also a correlation between the presence of estrogen receptors and histological signs of cell proliferation and tumor growth.