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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Differential integrin expression by T lymphocytes: Potential role in DMD muscle damage

2010; Elsevier BV; Volume: 223; Issue: 1-2 Linguagem: Inglês

10.1016/j.jneuroim.2010.03.006

ISSN

1872-8421

Autores

Fernanda Pinto‐Mariz, Luciana Rodrigues Carvalho, Wallace de Mello, Alexandra de Queiroz Campos Araújo, Márcia Gonçalves Ribeiro, Maria do Carmo Soares Alves Cunha, Thomas Voït, Gillian Butler‐Browne, Suse Dayse Silva-Barbosa, Wilson Savino,

Tópico(s)

Extracellular vesicles in disease

Resumo

The expression and function of integrin-type extracellular matrix receptors, VLA-4 and VLA-5, and laminin receptor VLA-6 on the surface of CD3(+)CD4(+) and CD3(+)CD8(+) defined T cell populations was evaluated in the blood of Duchenne muscular dystrophy (DMD) patients and healthy individuals. Both the number of CD4(+) and CD8(+) T cell subsets expressing VLA-4 or VLA-5 and the fibronectin-driven T cell migration was significantly higher in DMD patients. These data indicate that interactions of VLA-4 and/or VLA-5 with fibronectin may drive T lymphocytes to specific niches within muscle, contributing to tissue damage and fibrosis in DMD patients.

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