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Notch/RBP-J Signaling Regulates Epidermis/Hair Fate Determination of Hair Follicular Stem Cells

2003; Elsevier BV; Volume: 13; Issue: 4 Linguagem: Inglês

10.1016/s0960-9822(03)00081-2

1879-0445

Norio Yamamoto, Kenji Tanigaki, Hua Han, Hiroshi Hiai, Tasuku Honjo,

Neurogenesis and neuroplasticity mechanisms

Notch signaling is involved in the cell fate determination of various cell lineages [1Artavanis-Tsakonas S. Rand M.D. Lake R.J. Notch signaling cell fate control and signal integration in development.Science. 1999; 284: 770-776Crossref PubMed Scopus (4671) Google Scholar, 2MacDonald H.R. Wilson A. Radtke F. Notch1 and T-cell development insights from conditional knockout mice.Trends Immunol. 2001; 22: 155-160Abstract Full Text Full Text PDF PubMed Scopus (68) Google Scholar, 3Tanigaki K. Han H. Yamamoto N. Tashiro K. Ikegawa M. Kuroda K. Suzuki A. Nakano T. Honjo T. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.Nat. Immunol. 2002; 3: 443-450Crossref PubMed Scopus (377) Google Scholar, 4Han H. Tanigaki K. Yamamoto N. Kuroda K. Yoshimoto M. Nakahata T. Ikuta K. Honjo T. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision.Int. 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Biol. 1995; 5: 1416-1423Abstract Full Text Full Text PDF PubMed Scopus (390) Google Scholar] to transactivate transcription of target genes [10Jarriault S. Brou C. Logeat F. Schroeter E.H. Kopan R. Israel A. Signalling downstream of activated mammalian Notch.Nature. 1995; 377: 355-358Crossref PubMed Scopus (1195) Google Scholar, 12Honjo T. The shortest path from the surface to the nucleus RBP-Jκ/Su(H) transcription factor.Genes Cells. 1996; 1: 1-9Crossref PubMed Scopus (174) Google Scholar]. All four Notches in mammals [13Weinmaster G. Roberts V.J. Lemke G. A homolog of Drosophila Notch expressed during mammalian development.Development. 1991; 113: 199-205Crossref PubMed Google Scholar, 14Weinmaster G. Roberts V.J. Lemke G. Notch2a second mammalian Notch gene.Development. 1992; 116: 931-941Crossref PubMed Google Scholar, 15Kopan R. Weintraub H. Mouse notch expression in hair follicles correlates with cell fate determination.J. Cell Biol. 1993; 121: 631-641Crossref PubMed Scopus (126) Google Scholar, 16Lardelli M. Dahlstrand J. Lendahl U. The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium.Mech. Dev. 1994; 46: 123-136Crossref PubMed Scopus (258) Google Scholar, 17Uyttendaele H. Marazzi G. Wu G. Yan Q. Sassoon D. Kitajewski J. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene.Development. 1996; 122: 2251-2259Crossref PubMed Google Scholar] bind to RBP-J to exert their transactivation activities. Notch is expressed in developing or differentiating epidermis and hairs [13Weinmaster G. Roberts V.J. Lemke G. A homolog of Drosophila Notch expressed during mammalian development.Development. 1991; 113: 199-205Crossref PubMed Google Scholar, 14Weinmaster G. Roberts V.J. Lemke G. Notch2a second mammalian Notch gene.Development. 1992; 116: 931-941Crossref PubMed Google Scholar, 15Kopan R. 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Chambon P. et al.Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation.EMBO J. 2001; 20: 3427-3436Crossref PubMed Scopus (681) Google Scholar], and regulates hair differentiation [22Lin M.H. Leimeister C. Gessler M. Kopan R. Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers.Development. 2000; 127: 2421-2432PubMed Google Scholar]. The common stem cells that reside in the upper portion of hair follicles (the bulge) contribute to epidermal and hair cell formation [23Taylor G. Lehrer M.S. Jensen P.J. Sun T.T. Lavker R.M. Involvement of follicular stem cells in forming not only the follicle but also the epidermis.Cell. 2000; 102: 451-461Abstract Full Text Full Text PDF PubMed Scopus (916) Google Scholar, 24Oshima H. Rochat A. Kedzia C. Kobayashi K. Barrandon Y. Morphogenesis and renewal of hair follicles from adult multipotent stem cells.Cell. 2001; 104: 233-245Abstract Full Text Full Text PDF PubMed Scopus (838) Google Scholar]. However, it is unknown what determines whether hair follicular stem cells will become hairs or epidermis. Here we report that conditionally disrupting the mouse RBP-J gene in a mosaic pattern to avoid embryonic lethality of RBP-J-deficiency [25Oka C. Nakano T. Wakeham A. de la Pompa J.L. Mori C. Sakai T. Okazaki S. Kawaichi M. Shiota K. Mak T.W. et al.Disruption of the mouse RBP-Jκ gene results in early embryonic death.Development. 1995; 121: 3291-3301Crossref PubMed Google Scholar] caused hair loss, epidermal hyperkeratinization, and epidermal cyst formation. Cyst formation is probably due to a combination of the aberrant fate determination of RBP-J-deficient stem cells to epidermal progenitors and their accelerated differentiation into epidermis. These results suggest that Notch/RBP-J signaling regulates the cell fate determination of hair follicular stem cells at the bulge region.