A Comparison of Intrathecal Analgesia with Fentanyl or Sufentanil After Total Hip Replacement
2000; Lippincott Williams & Wilkins; Volume: 9; Issue: 4 Linguagem: Inglês
10.1097/00000539-200004000-00026
ISSN1526-7598
AutoresRoxane Fournier, Elizabeth Van Gessel, Anne Weber, Zdravko Gamulin,
Tópico(s)Anesthesia and Sedative Agents
ResumoWe designed this study to compare the postoperative analgesic effects of intrathecal fentanyl and sufentanil, the end points being onset, quality, and duration of action. A total of 42 geriatric patients, scheduled for elective total hip replacement under continuous spinal anesthesia, were randomized in two double-blinded groups as soon as they experienced a pain score higher than 3 of 10 on the visual analog scale in the recovery room. Either 7.5 μg sufentanil or 40 μg fentanyl in 2 mL normal saline were intrathecally administered. Pain scores, rescue analgesia (ketorolac and morphine), and adverse effects (respiratory depression, postoperative nausea and vomiting, and itching) were recorded for 24 h after surgery. In both groups, comparing sufentanil to fentanyl, the time to a pain score 3 (241 ± 102 vs 214 ± 120 min) were comparable as were the analgesic requirements during the first 24 h. We conclude that, after total hip replacement, both lipid soluble opioids produce excellent analgesia with comparable onset, duration of action, and low incidence of minor adverse effects. Implications: We compared the postoperative analgesic properties of 40 μg intrathecal fentanyl and 7.5 μg sufentanil after total hip replacement. Both opioids provided satisfactory analgesia, with comparable onset (11 ± 8 vs 9 ± 9 min) and duration of action (214 ± 120 vs 241 ± 102 min), as well as low incidence of minor side effects.
Referência(s)