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Neuropsychological impairments in elderly Neurofibromatosis type 1 patients

2014; Elsevier BV; Volume: 57; Issue: 5 Linguagem: Inglês

10.1016/j.ejmg.2014.02.004

1878-0849

Danielle de Souza Costa, Jonas Jardim de Paula, Nilton Alves de Rezende, Luiz Oswaldo Carneiro Rodrigues, Leandro Fernandes Malloy‐Diniz, Marco Aurélio Romano‐Silva, Débora Marques de Miranda,

Vascular Malformations Diagnosis and Treatment

Cognitive performance is compromised in Neurofibromatosis type 1 (NF1) patients, but neuropsychological data including elderly NF1 are extremely sparse. We compared the cognitive performance of a small elderly NF1 group (n = 5) with an age-matched healthy control group (n = 49). NF1 group performed worse than control group on a global cognitive impairment task, verbal working memory, and visuospatial functioning. The results suggest that cognitive impairment is an important feature of NF1 across lifespan, including elderly individuals. Future studies approaching the NF1 cognitive profile might benefit from looking at the mechanisms linked to the age-related aspects of cognitive decline.