Produção Nacional
Revisado por pares
SR 141716A prevents Δ9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice
2002; Elsevier BV; Volume: 26; Issue: 2 Linguagem: Inglês
10.1016/s0278-5846(01)00275-5
ISSN1878-4216
AutoresGeorge E. Da Silva, Reinaldo Ν. Takahashi,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoThis study reports a series of spatial discrimination procedures in a Morris-type maze to investigate the effects of Δ9-tetrahydrocannabinol (Δ9-THC) on different phases of learning and memory in mice. Adult male mice were given training trails to find the submerged platform at a fixed location in the water maze adapted for mice. In additional experiments, mice were trained with the repeated acquisition procedure to test the working memory. Results indicate that Δ9-THC (8 mg/kg ip) 30 min pretest impaired specifically the acquisition of spatial learning and the performance of mice in the working memory task, while consolidation and retrieval of a previously learned task were not affected. There was no evidence of motoric difficulty, as the number of quadrant line crossings was not decreased and no visible sign of sensorimotor disturbance was observed during swimming. Pretreatment with SR 141716A (1 mg/kg ip), a CB1 cannabinoid receptor antagonist, significantly prevented the learning deficits in the water maze. These findings show that Δ9-THC impairs spatial discrimination learning in a selective way in the water maze in mice and that these deficits may be mediated by cannabinoid receptors.
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