COMPARISON OF AUREOMYCIN AND CHLORAMPHENICOL IN TREATMENT OF BACTERIAL PNEUMONIA
1951; American Medical Association; Volume: 147; Issue: 2 Linguagem: Inglês
10.1001/jama.1951.03670190010003
ISSN2376-8118
Autores Tópico(s)Antibiotics Pharmacokinetics and Efficacy
ResumoPneumococcic pneumonia has been found to respond to aureomycin therapy in a manner comparable to that observed with penicillin. A rapid defervescence was noted in 31 of 33 patients treated by Gocke, Collins, and Finland, 1 and there were only two deaths, both occurring within 18 hr. after starting therapy. Dowling and others 2 reported a case fatality rate of 1.5% among 131 cases of pneumococcic pneumonia treated with aureomycin, as compared with a rate of 5.2% in 686 cases treated with penicillin. Much less is known concerning the effectiveness of chloramphenicol in the treatment of pneumococcic pneumonia. This antibiotic has been reported by Bliss and Todd 3 to have little effect on the course of pneumococcic infections in mice. In man, however, clinical studies in a small number of patients have yielded encouraging results. 4 The following study, carried out during the first six months of 1950, was undertaken
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