Effect of Nonsteroidal Anti-Inflammatory Agents and Finasteride on Prostate Cancer Risk
2002; Lippincott Williams & Wilkins; Volume: 168; Issue: 5 Linguagem: Inglês
10.1016/s0022-5347(05)64277-2
ISSN1527-3792
AutoresJacques Irani, V. Ravery, Jérémie Pariente, Emmanuel Chartier‐Kastler, E. Lechevallier, M. Soulié, Denis Chautard, P. Coloby, Éric Fontaine, Franck Bladou, F. Desgrandchamps, O. Haillot,
Tópico(s)Estrogen and related hormone effects
ResumoNo AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Nov 2002Effect of Nonsteroidal Anti-Inflammatory Agents and Finasteride on Prostate Cancer Risk J. IRANI, V. RAVERY, J.L. PARIENTE, E. CHARTIER-KASTLER, E. LECHEVALLIER, M. SOULIÉ, D. CHAUTARD, P. COLOBY, E. FONTAINE, F. BLADOU, F. DESGRANDCHAMPS, and O. HAILLOT J. IRANIJ. IRANI , V. RAVERYV. RAVERY , J.L. PARIENTEJ.L. PARIENTE , E. CHARTIER-KASTLERE. CHARTIER-KASTLER , E. LECHEVALLIERE. LECHEVALLIER , M. SOULIÉM. SOULIÉ , D. CHAUTARDD. CHAUTARD , P. COLOBYP. COLOBY , E. FONTAINEE. FONTAINE , F. BLADOUF. BLADOU , F. DESGRANDCHAMPSF. DESGRANDCHAMPS , and O. HAILLOTO. HAILLOT View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64277-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We examine the relationship of nonsteroidal anti-inflammatory drugs and finasteride on the risk of prostate cancer. Materials and Methods: Participants in this case control study using a prospective collection of data were drawn from consecutive patients who underwent prostate biopsy at 12 different departments of urology from January 1999 to June 2000. Medication use was assessed by self-questionnaire as well as questions about dietary and lifestyle factors that might be relevant for prostate cancer risk. Results: The study included 639 patients with prostate cancer and 659 cancer-free controls. Univariate analysis showed no significant impact of aspirin and finasteride on prostate cancer risk while the nonaspirin nonsteroidal anti-inflammatory drug users had a lower risk (OR 0.80, 95% CI 0.64–0.99). After adjusting for potential confounders, the protective effect of nonaspirin nonsteroidal anti-inflammatory drugs was no longer significant (OR, 0.84, 95% CI 0.66–1.07), while finasteride showed a significant protective effect (OR 0.58, 95% CI 0.37–0.92). 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Google Scholar From the University Hospital of Poitiers, Poitiers, Bichat Hospital, La Pitié Hospital, Ambroise Paré Hospital and St. Louis Hospital, Paris, University Hospital of Bordeaux, Bordeaux, University Hospital Marseille, Marseille, University Hospital of Toulouse, Toulouse, University Hospital of Angers, Angers, Hospital of Pontoise, Pontoise and University Hospital of Tours, Tours, France© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byPatel M, Kurek C and Dong Q (2018) The Arachidonic Acid Pathway and its Role in Prostate Cancer Development and ProgressionJournal of Urology, VOL. 179, NO. 5, (1668-1675), Online publication date: 1-May-2008.BASLER J and PIAZZA G (2018) Nonsteroidal Anti-inflammatory Drugs and Cyclooxygenase-2 Selective Inhibitors for Prostate Cancer ChemopreventionJournal of Urology, VOL. 171, NO. 2S, (S59-S63), Online publication date: 1-Feb-2004.NELSON W, DE MARZO A, DeWEESE T and ISAACS W (2018) THE ROLE OF INFLAMMATION IN THE PATHOGENESIS OF PROSTATE CANCERJournal of Urology, VOL. 172, NO. 5S, (S6-S12), Online publication date: 1-Nov-2004. Volume 168Issue 5November 2002Page: 1985-1988 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordschemopreventionfinasteridecyclooxygenase inhibitorsprostatic neoplasmsMetricsAuthor Information J. IRANI More articles by this author V. RAVERY More articles by this author J.L. PARIENTE More articles by this author E. CHARTIER-KASTLER More articles by this author E. LECHEVALLIER More articles by this author M. SOULIÉ More articles by this author D. CHAUTARD More articles by this author P. COLOBY More articles by this author E. FONTAINE More articles by this author F. BLADOU More articles by this author F. DESGRANDCHAMPS More articles by this author O. HAILLOT More articles by this author Expand All Advertisement PDF downloadLoading ...
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