Methotrexate: a detailed review on drug delivery and clinical aspects
2012; Taylor & Francis; Volume: 9; Issue: 2 Linguagem: Inglês
10.1517/17425247.2012.642362
ISSN1744-7593
AutoresZulfequar Ahamad Khan, Rahul Tripathi, Brahmeshwar Mishra,
Tópico(s)Rheumatoid Arthritis Research and Therapies
ResumoIntroduction: Uses of methotrexate (MTX) are well established for the treatment of various types of malignancy, psoriasis, rheumatological diseases and the medical termination of pregnancy. Formulation and targeting approaches for MTX with controlled release carriers, multiparticulate systems, prodrug and drug conjugates have been found to improve bioavailability, reduce adverse effects and maximize clinical efficacy, compared with conventional methods.
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