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Gadofosveset-enhanced magnetic resonance angiography

2008; Dove Medical Press; Volume: 4; Issue: 1 Linguagem: Inglês

10.2147/vhrm.2008.04.01.1

1178-2048

Mathias Goyen,

Lanthanide and Transition Metal Complexes

Gadofosveset (Vasovist ® , Bayer Schering Pharma AG, Berlin/Germany) is the fi rst intravascular contrast agent approved for use with magnetic resonance angiography in the European Union, Switzerland, Turkey, Canada, and Australia.Gadofosveset reversibly binds to albumin providing extended intravascular enhancement compared wth existing extracellular magnetic resonance contrast agents.Prior to approval, gadofosveset underwent extensive testing to evaluate the safety and effi cacy of the drug; the clinical trials show that gadofosveset-enhanced magnetic resonance angiography (MRA) is safe and well tolerated in patients with vascular disease and effective for the detection of vascular stenosis and aneurysms gadofosveset has the potential to open new horizons in diagnostic MRA by increasing the spatial resolution and the robustness of MRA examinations and facilitating the examination of multiple vascular beds.