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Atypical Hemophagocytic Lymphohistiocytosis Following Bacterial Tonsillitis in Acute Lymphoblastic Leukemia

2003; Taylor & Francis; Volume: 44; Issue: 7 Linguagem: Inglês

10.1080/1042819031000079078

1042-8194

Toshio Kakihara, Chihaya Imai, Takayuki Kaneko, Atsushi Tanaka, Makoto Uchiyama,

Inflammasome and immune disorders

We report a rare case of acute lymphoblastic leukemia (ALL) who developed dyspnea, neurological disturbance with illusions, pancytopenia, phagocytosis and coagulation disturbances following bacterial tonsillitis. The values of soluble interleukin-2 receptor (sIL-2R), IL-6 and IL-8 were also elevated. Her clinicolaboratory findings were similar to hemophagocytic lymphohistiocytosis (HLH), which is a cytokine disease induced by activated T cells and macrophages. Atypical HLH following bacterial tonsillitis should be kept in mind in leukemia patients.