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Interleukin-8 and Related Chemotactic Cytokines

1994; Elsevier BV; Volume: 105; Issue: 3 Linguagem: Inglês

10.1378/chest.105.3_supplement.95s

1931-3543

Marco Baggiolini, Bernhard Moser, Ian Clark‐Lewis,

T-cell and B-cell Immunology

Interleukin-8 (IL-8) is the best known representative of a new class of chemotactic cytokines, now called chemokines, which activate leukocytes, and are widely studied because of their role as novel mediators of inflammation. 1 Baggiolini M Clark-Lewis I Interleukin-8, a chemotactic and inflammatory cytokine. FEBS Lett. 1992; 307: 97-101 Abstract Full Text PDF PubMed Scopus (719) Google Scholar , 2 Baggiolini M Dewald B Moser B Interleukin-8 and related chemotactic cytokines CXC and CC chemokines. Adv Immunol. 1993; 55: 97-179 Crossref Scopus (2258) Google Scholar Two subfamilies of chemokines are distinguished according to the arrangement of the first two of four conserved cysteines, which are either separated by one amino acid (CXC chemokines) or adjacent (CC chemokines). The CXC chemokines act mainly on neutrophil leukocytes, while CC chemokines have a broader spectrum of activities and can stimulate monocytes, basophils, eosinophils, and even lymphocytes. 2 Baggiolini M Dewald B Moser B Interleukin-8 and related chemotactic cytokines CXC and CC chemokines. Adv Immunol. 1993; 55: 97-179 Crossref Scopus (2258) Google Scholar The genes of the two subfamilies are clustered on different chromosomes, number 4 for the CXC and number 17 for the CC chemokines. 2 Baggiolini M Dewald B Moser B Interleukin-8 and related chemotactic cytokines CXC and CC chemokines. Adv Immunol. 1993; 55: 97-179 Crossref Scopus (2258) Google Scholar