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Antiulcer action of sophora flavescens root and an active constituent. I

1990; Elsevier BV; Volume: 29; Issue: 2 Linguagem: Inglês

10.1016/0378-8741(90)90053-v

1872-7573

Johji Yamahara, Michihiko Mochizuki, Hajimè Fujimura, Yoshihisa Takaishi, Masaaki Yoshida, Toshiaki Tomimatsu, Yoshin Tamai,

Natural product bioactivities and synthesis

The effect of a methanol extract of Sophora flavescens root was examined on gastric ulcers induced in rats by HCl/ethanol in order to substantiate its reputed protective properties. Oral doses of 1 g/kg completely suppressed ulceration. Results suggest that oral administration of 50 mg/kg of vexibinol, a flavanol found in the extract, inhibited ulceration more effectively than spizofurone at 100 mg/kg.