Epidermal Growth Factor Receptors in Genetically Induced Hyperproliferative Skin Disorders
1990; Wiley; Volume: 7; Issue: 4 Linguagem: Inglês
10.1111/j.1525-1470.1990.tb01021.x
ISSN1525-1470
AutoresLillian B. Nanney, Lloyd E. King, Beverly A. Dale,
Tópico(s)Skin and Cellular Biology Research
ResumoAbstract: The presence and morphologic distribution of epidermal growth factor receptor (EGF‐R) were investigated in a variety of genetic disorders that affect human epidermis. These diseases included various forms of ichthyoses as well as restrictive dermopathy and the CHILD syndrome (congenital hemidysplasia‐ichthyosiform erythroderma‐limb defects). The distribution of EGF‐R was detected by immunohistochemical techniques. Increased staining of immunoreactive EGF‐R was frequently, but not always, seen in lesions with experimental or clinical evidence of hyperproliferation, suggesting an increased potential to respond to endogenous levels of either transforming growth factor‐α or EGF. The finding that EGF‐R levels are not always increased in congenital epidermal disorders indicated that the presence of this receptor pathway is not simply a marker for aberrant epidermis.
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