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Randomized Comparison of OASIS Wound Matrix versus Moist Wound Dressing in the Treatment of Difficult-to-Heal Wounds of Mixed Arterial/Venous Etiology

2009; Lippincott Williams & Wilkins; Volume: 23; Issue: 1 Linguagem: Inglês

10.1097/01.asw.0000363485.17224.26

1538-8654

Marco Romanelli, Valentina Dini, Maria Stefania Bertone,

Electrospun Nanofibers in Biomedical Applications

In Brief OBJECTIVE: In this study, a biological extracellular matrix was compared with a moist wound dressing to determine its effectiveness in the treatment of mixed arterial/venous and venous ulcers. METHODS: Patients were evaluated for complete wound healing, time to dressing change, and formation of granulation tissue. RESULTS: Extracellular matrix-treated ulcers achieved complete healing on average in 5.4 weeks as compared with 8.3 weeks for the control group treated with moist wound dressing (P = .02). At the primary time point evaluated (8 weeks), complete wound closure was achieved in 80% of extracellular matrix-treated ulcers compared with 65% of ulcers in the control group (P < .05). Statistically significant differences favoring the extracellular-matrix treatment group were also reported for time to dressing change (P < .05), and for percentage of granulation tissue formed (P < .05). CONCLUSION: Overall, the biological extracellular matrix was more beneficial than moist wound dressings for the treatment of patients with mixed arterial/venous or venous ulcers. In this study, a biological extracellular matrix was compared with a moist wound dressing to determine its effectiveness in the treatment of mixed arterial/venous and venous ulcers.