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Chronic kidney disease with three cases of oxalate-like nephrosis in Ragdoll cats

2008; SAGE Publishing; Volume: 11; Issue: 6 Linguagem: Inglês

10.1016/j.jfms.2008.11.003

1532-2750

Reidun Heiene, Gill Rumsby, Martine Lund Ziener, S Dahl, Christopher Tims, Jon Teige, Nina Ottesen,

Kidney Stones and Urolithiasis Treatments

Two unrelated Ragdoll cat mothers in Norway were found dead from renal disease. The histopathology was consistent with oxalate nephrosis with chronic or acute-on-chronic underlying kidney disease. Both cats had offspring and relatives with signs of urinary tract disease, including a kitten dead with urethral gravel. Eleven living Ragdoll cats, including nine relatives of the dead cats and the male father of a litter with similarly affected animals, were tested for primary hyperoxaluria (PH) type 1 and 2 by urine oxalate and liver enzyme analysis. Renal ultrasound revealed abnormalities in five living cats. One of these was azotaemic at the time of examination and developed terminal kidney disease 9 months later. A diagnosis of PH was excluded in 11 cats tested. The inheritance and aetiological background of the renal disease present in the breed remains unresolved at this point in time.