Minoxidil and pericardial effusion: An idiosyncratic reaction
1981; Wiley; Volume: 30; Issue: 1 Linguagem: Inglês
10.1038/clpt.1981.128
ISSN1532-6535
Autores Tópico(s)Infective Endocarditis Diagnosis and Management
ResumoClinical Pharmacology & TherapeuticsVolume 30, Issue 1 p. 64-70 Original Article Minoxidil and pericardial effusion: An idiosyncratic reaction Michael J Reichgott MD, PhD, Corresponding Author Michael J Reichgott MD, PhD Section of Hypertension and Clinical Pharmacology, Department of Medicine, Hospital of the University of PennsylvaniaDr M J Reichgott, Veterans Administration Medical Center, 39th and Woodland Ave., Philadelphia, PA 19104.Search for more papers by this author Michael J Reichgott MD, PhD, Corresponding Author Michael J Reichgott MD, PhD Section of Hypertension and Clinical Pharmacology, Department of Medicine, Hospital of the University of PennsylvaniaDr M J Reichgott, Veterans Administration Medical Center, 39th and Woodland Ave., Philadelphia, PA 19104.Search for more papers by this author First published: July 1981 https://doi.org/10.1038/clpt.1981.128Citations: 4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Minoxidil is a new potent antihypertensive vasodilator. Although highly effective, its use is limited by the association of the drug with pericardial effusion. We examined possible relationships in 37 patients. There were two significant effusions identified by echocardiography in 22 patients under active treatment. Retrospective review of 15 additional patients no longer under treatment identified seven who had had effusion and one who had had transient pericarditis. Resolution of effusion accompanied withdrawal in five patients; rechallenge was followed by effusion in one patient. Ninety-one episodes of pericardial disease have been reported in 1,869 experimental subjects (4.8%). Pericardial tamponade occurred in 21, with eight associated deaths. There are no specific patient characteristics that predict the likelihood of effusion. Since the reaction is both idiosyncratic and potentially fatal, it seems appropriate to continue to limit the use of minoxidil. Clinical Pharmacology and Therapeutics (1981) 30, 64–70; doi:10.1038/clpt.1981.128 Citing Literature Volume30, Issue1July 1981Pages 64-70 RelatedInformation
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