Portal de Periódicos da CAPES

Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells

2009; Wiley; Volume: 148; Issue: 1 Linguagem: Inglês

10.1111/j.1365-2141.2009.07929.x

1365-2141

Ernesto Pérez Persona, Gema Mateo, Ramón García‐Sánz, María‐Victoria Mateos, Natalia de las Heras, Alfonso García de Coca, José M. Hernández, Josefina Galende, Guillermo Martín–Núñez, Abelardo Bárez, José María Alonso, Alejandro Martı́n, C López-Berges, Alberto Órfão, Jesús F. San Miguel, María‐Belén Vidriales,

Platelet Disorders and Treatments

The present study explored the impact of two novel criteria; having >95% abnormal plasma cells by flow cytometry at diagnosis and the evolving subtype of the disease, as predictors of progression in 61 smouldering multiple myeloma (SMM) and 311 monoclonal gammopathy of unknown significance (MGUS) patients. Although both criteria were of prognostic value, the risk of progression was better identified by immunophenotyping [Hazard Ratio (HR) 6.2 and 17.2 for SMM and MGUS, respectively] than evolving subtype, which had independent prognostic value only in MGUS (HR 3.6). Immunophenotyping discriminated the different risk of progression within the evolving and non-evolving subgroups of SMM (P = 0.01) and MGUS (P < 0.001).