Significance of glutathione S-transferase-π as a tumor marker in patients with oral cancer
1992; Wiley; Volume: 70; Issue: 10 Linguagem: Inglês
10.1002/1097-0142(19921115)70
ISSN1097-0142
AutoresS. Hirata, Tetsuyo ODAJIMA, Gen-iku KOHAMA, Seishi Ishigaki, Yoshiro Niitsu,
Tópico(s)Kruppel-like factors research
ResumoBackground. The authors analyzed the clinical usefulness of glutathione-S-transferase-π (GST-π) as a tumor marker in patients with oral cancer. Methods. GST-π levels in plasma of 61 patients with oral squamous cell carcinomas, 65 patients with benign oral diseases, and 78 healthy subjects were investigated with the sandwich enzyme-immunoassay (EIA) system. Results. Elevated GST-π levels in plasma were observed in patients with oral cancer, but patients with benign oral diseases had normal GST-π levels. More than 70% of patients with Stage III or IV oral cancer and more than 50% of those with Stage I and II disease had elevated levels of GST-π in plasma. Elevated levels of GST-π in plasma were also discovered in most patients with tumor recurring after surgery before recurrence was detected clinically. GST-π also was found to be a useful marker for evaluating the response to chemotherapy, for monitoring postoperative tumor resectability or tumor burden, and for predicting the recurrence of tumor in patients with oral cancer. Conclusions. GST-π is considered to be a useful aid for early diagnosis, predicting tumor extent, and determining parameters of treatment efficacy and prognosis for oral cancer.
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