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Direct Electrical Measurements on Single-Molecule Genomic DNA Using Single-Walled Carbon Nanotubes

2007; American Chemical Society; Volume: 8; Issue: 1 Linguagem: Inglês

10.1021/nl0716451

1530-6992

Somenath Roy, Harindra Vedala, Aparna Datta Roy, Dohyun Kim, Melissa Doud, Kalai Mathee, Hoon-Kyu Shin, Nobuo Shimamoto, Viswanath Prasad, Wonbong Choi,

Nanopore and Nanochannel Transport Studies

A unique nanoelectronic platform, based on single-walled carbon nanotubes (SWNTs), has been fabricated for measuring electrical transport in single-molecule DNA. We have tested 80 base pairs of single- and double-stranded DNA (ssDNA and dsDNA, respectively) of complex base sequences. About a 25−40 pA current (at 1 V) was measured for the dsDNA molecule covalently attached to the SWNT electrode at its termini. In the absence of base pair stacking, a ssDNA carries a feeble current of ∼1 pA or less. Gate-voltage-dependent I−V characteristics revealed that the bridging dsDNA molecule acts as a p-type channel between SWNT source and drain electrodes.