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Definition of reference ranges for the platelet distribution width (PDW): a local need

2009; De Gruyter; Volume: 48; Issue: 2 Linguagem: Inglês

10.1515/cclm.2010.035

1437-4331

Mariela Granero Farias, Elias Guilherme Schunck, Suzane Dal Bó, Simone Martins de Castro,

Antiplatelet Therapy and Cardiovascular Diseases

Abstract Background: Automated hematological analyzers have contributed to more precise and faster results. They also make it possible to measure several blood cell parameters automatically. Among the parameters provided, platelet indices are probably the most ignored by clinical laboratories due to the difficulty of standardization, as well as being affected by a range of methodological problems. It has been suggested that each laboratory determines its own reference intervals with the equipment used. Methods: Our goal was to determine the reference range of platelet distribution width (PDW) in venous blood samples from 231 patients using the Pentra 120 ABX hematology analyzer. Results: The PDW median was 13.3%, with a reference range of 10.0%–17.9% for the 5th–95th percentiles, with a confidence interval of 95%. Conclusions: Among all indices, the PDW has been receiving attention due to its usefulness for distinguishing between reactive thrombocytosis and thrombocytosis associated with myeloproliferative disorder. Determination of the PDW reference range is fundamental, and the association of this parameter with the platelet number and mean platelet volume may be used for the diagnosis and differentiation of several pathologies. Clin Chem Lab Med 2010;48:255–7.