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MDR1 and CYP3A4 polymorphisms among African, Indian, and white populations in KwaZulu-Natal, South Africa

2003; Wiley; Volume: 74; Issue: 2 Linguagem: Inglês

10.1016/s0009-9236(03)00151-6

1532-6535

Paul Kiprono Chelule, Michelle Gordon, Thesla Palanee‐Phillips, Taryn Page, Anisa Mosam, Hoosen Coovadia, Sharon Cassol,

HIV Research and Treatment

Clinical Pharmacology & TherapeuticsVolume 74, Issue 2 p. 195-196 Letters to the Editor MDR1 and CYP3A4 polymorphisms among African, Indian, and white populations in KwaZulu-Natal, South Africa Paul K. Chelule MMedSc, Paul K. Chelule MMedSc HIV-1 Molecular Virology and Bioinformatics Laboratory, Africa Centre for Health and Population Studies, Nelson R. Mandela School of Medicine, University of Natal, Durban, South AfricaSearch for more papers by this authorMichelle Gordon MMedSc, Michelle Gordon MMedSc HIV-1 Molecular Virology and Bioinformatics Laboratory, Africa Centre for Health and Population Studies, Nelson R. Mandela School of Medicine, University of Natal, Durban, South AfricaSearch for more papers by this authorThesla Palanee MMedSc, Thesla Palanee MMedSc HIV-1 Molecular Virology and Bioinformatics Laboratory, Africa Centre for Health and Population Studies, Nelson R. Mandela School of Medicine, University of Natal, Durban, South AfricaSearch for more papers by this authorTaryn Page BTech, Taryn Page BTech HIV-1 Molecular Virology and Bioinformatics Laboratory, Africa Centre for Health and Population Studies, Nelson R. Mandela School of Medicine, University of Natal, Durban, South AfricaSearch for more papers by this authorAnisa Mosam FC Derm, Anisa Mosam FC Derm Department of Dermatology, Nelson R. Mandela School of Medicine, University of Natal, Durban, South AfricaSearch for more papers by this authorH. M. Coovadia MD, H. M. Coovadia MD Centre for HIV/AIDS Networking, Nelson R. Mandela School of Medicine, University of Natal, Durban, South AfricaSearch for more papers by this authorSharon Cassol PhD, Sharon Cassol PhD Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United KingdomSearch for more papers by this author Paul K. Chelule MMedSc, Paul K. Chelule MMedSc HIV-1 Molecular Virology and Bioinformatics Laboratory, Africa Centre for Health and Population Studies, Nelson R. Mandela School of Medicine, University of Natal, Durban, South AfricaSearch for more papers by this authorMichelle Gordon MMedSc, Michelle Gordon MMedSc HIV-1 Molecular Virology and Bioinformatics Laboratory, Africa Centre for Health and Population Studies, Nelson R. Mandela School of Medicine, University of Natal, Durban, South AfricaSearch for more papers by this authorThesla Palanee MMedSc, Thesla Palanee MMedSc HIV-1 Molecular Virology and Bioinformatics Laboratory, Africa Centre for Health and Population Studies, Nelson R. Mandela School of Medicine, University of Natal, Durban, South AfricaSearch for more papers by this authorTaryn Page BTech, Taryn Page BTech HIV-1 Molecular Virology and Bioinformatics Laboratory, Africa Centre for Health and Population Studies, Nelson R. Mandela School of Medicine, University of Natal, Durban, South AfricaSearch for more papers by this authorAnisa Mosam FC Derm, Anisa Mosam FC Derm Department of Dermatology, Nelson R. Mandela School of Medicine, University of Natal, Durban, South AfricaSearch for more papers by this authorH. M. Coovadia MD, H. M. Coovadia MD Centre for HIV/AIDS Networking, Nelson R. Mandela School of Medicine, University of Natal, Durban, South AfricaSearch for more papers by this authorSharon Cassol PhD, Sharon Cassol PhD Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United KingdomSearch for more papers by this author First published: 05 August 2003 https://doi.org/10.1016/S0009-9236(03)00151-6Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Kim, R. B., Leake, B. F., Dresser, G. K., Kubba, S. V. and Schwarz, U. I., et al. (2001). Identification of functional variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther. 70: 189–199. 2Kurata, Y., Ieiri, I., Kimura, M., Morita, T., Irie, S. and Urae, A., et al. (2002). Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein. Clin Pharmacol Ther. 72: 209–219. 3Wandel, C., White, J. S., Hall, J. M., Stein, M., Wood, A. J. J. and Wilkinson, G. R. (2000). CYP3A activity in African American and European American men: population differences and functional effect of CYP3A4*1B 5′-promoter region polymorphism. Clin Pharmacol Ther. 68: 82–91. 4Cavalli, S. A., Hirata, M. H. and Hirata, R. D. C. (2001). Detection of Mbo II polymorphism at the 5′-promoter regions of CYP3A4. Clin Chem. 47: 348–351. 5Ameyaw, M., Regateiro, F., Li, T., Liu, X., Tariq, M. and Mobarek, A., et al. (2002). MDR1 pharmacogenetics: frequency of C3435T mutation in exon 26 is significantly influenced by ethnicity. Pharmacogenetics. 11: 217–221. Citing Literature Volume74, Issue2August 2003Pages 195-196 ReferencesRelatedInformation