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Local enkephalins tonically modulate dopamine release in the striatum: a microdialysi study

1990; Elsevier BV; Volume: 524; Issue: 1 Linguagem: Inglês

10.1016/0006-8993(90)90505-6

1872-6240

Nathalie Dourmap, Adina T. Michael‐Titus, Jean Costentin,

Pain Mechanisms and Treatments

Kelatorphan, an inhibitor of the enkephalin-degrading enzymes, infused by microdialysis (10(-6) M) in the striatum of anaesthetized rats, significantly increased dopamine (DA) output but left dihydroxyphenylacetic acid and homovanillic acid extracellular levels unchanged. The local application of naltrexone (10(-6) M) prevented the effect of kelatorphan on DA release. These data indicate that local enkephalins tonically modulate DA release in rat striatum.