Dextromethorphan and dextrorphan as calcium channel antagonists
1988; Elsevier BV; Volume: 439; Issue: 1-2 Linguagem: Inglês
10.1016/0006-8993(88)91497-7
ISSN1872-6240
AutoresCelia L. Carpenter, Shelley S. Marks, D. Watson, David A. Greenberg,
Tópico(s)Lipid Membrane Structure and Behavior
ResumoDextromethorphan and dextrorphan, which reduce excitatory amino acid-induced neurotoxicity, decreased K+ depolarization-evoked 45Ca2+ uptake into brain synaptosomes and cultured neural (PC12) cells. Half-maximal inhibition of synaptosomal 45Ca2+ uptake occurred with 48 μM dextromethorphan or 200 μM dextrorphan, which are similar to concentrations associated with protection from excitotoxicity. The ability to decrease Ca2+ flux through N-type (synaptosomal) and L-type (PC12) voltage-gated Ca2+ channels may therefore contribute to the neuroprotective effects of these compounds.
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