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Identification of nucleus‐encoded F 0 I protein of bovine heart mitochondrial H + ‐ATPase as a functional part of the F 0 moiety

1988; Wiley; Volume: 237; Issue: 1-2 Linguagem: Inglês

10.1016/0014-5793(88)80161-3

1873-3468

Franco Zanotti, F. Guerrieri, G. Capozza, J Houštěk, Severino Ronchi, Sergio Papa,

RNA and protein synthesis mechanisms

The F 0 I protein of apparent M r 27000, previously characterized [(1988) Eur. J. Biochem. 173, 1–8] as a genuine component of bovine heart F 0 , has been sequenced and shown to be identical with the nucleus encoded 24668 Da protein characterized earlier [(1987) J. Mol. Biol. 197, 89–100]. It is directly shown by proteolytic cleavage and reconstitution experiments that this protein, denoted here as PVP from the single‐letter codes of the last three residues of the N‐terminus, is involved in proton conduction by F 0 and in its sensitivity to oligomycin.