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Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy

2009; Wiley; Volume: 64; Issue: 9 Linguagem: Inglês

10.1111/j.1398-9995.2009.02006.x

1398-9995

Guicheng Zhang, S.‐K. Khoo, Tiina Laatikainen, Pirkka T. Pekkarinen, Erkki Vartiainen, Leena von Hertzen, C. M. Hayden, Jack Goldblatt, Mika J. Mäkelä, Tari Haahtela, Peter N. Le Souëf,

Respiratory and Cough-Related Research

Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between ‘Western’ and ‘Eastern’ environments. Objectives: We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Methods: Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C‐159T and CC16 A38G. Results: For both CD14 C‐159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C‐159T, an interactive effect on ever itchy rash ( P interaction = 0.004), itchy rash <12 mo ( P interaction = 0.001) and dry cough at night in the past 12 months (<12 months) ( P interaction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis ( P interaction = 0.006), rhinitis <12 mo ( P interaction = 0.004), and marginally significant for ever hayfever ( P interaction = 0.07), allergic eye symptoms <12 mo ( P interaction = 0.09); their risk allele was G in Russians and A in Finns. Conclusion: An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women.