Synthesis and assembly of MHC-peptide complexes
1995; Elsevier BV; Volume: 16; Issue: 7 Linguagem: Inglês
10.1016/0167-5699(95)80157-x
ISSN1355-8242
AutoresAdam M. Benham, A. Tulp, Jacques Neefjes,
Tópico(s)Immune Cell Function and Interaction
ResumoRheumatoid arthritis is an autoimmune disease with a strong association with DR4 in many populations. In the Thai population, rheumatoid arthritis is associated with DRB1∗0405. To evaluate the role of polymorphism in TAP and HLA-DM genes, which are important in antigen processing and presentation in predisposition to rheumatoid arthritis, 82 Thai patients with rheumatoid arthritis and 100 unrelated normal controls were studied. TAP and HLA-DM typing was performed by ARMS-PCR and PCR-SSO method, respectively. There was no difference in the distribution of TAP1, TAP2, DMA, and DMB genes between the patients and controls. This study suggested that TAP and HLA-DM genes do not confer susceptibility to rheumatoid arthritis.
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