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NF- κ B activation in cerebrospinal fluid cells from patients with meningitis

2002; Taylor & Francis; Volume: 24; Issue: 7 Linguagem: Inglês

10.1179/016164102101200627

1743-1328

Takashi Ichiyama, Hiroshi Isumi, Tomomi Yoshitomi, Miki Nishikawa, Tomoyo Matsubara, Susumu Furukawa,

Inflammasome and immune disorders

We examined whether or not NF-kappaB, a factor that regulates expression of the genes that code for pro-inflammatory cytokines, is activated in cerebrospinal fluid (CSF) cells to investigate the production of pro-inflammatory cytokines by CSF cells in patients with meningitis. Western blotting demonstrated that NF-kappaB was more activated in CSF cells of patients with bacterial meningitis than in those of patients with aseptic meningitis. NF-kappaB was hardly activated in carcinomatous meningitis. The NF-kappaB activation in CSF cells of patients with meningitis tended to be correlated with the CSF interleukin-6 concentration. Our data suggested that CSF cells produce pro-inflammatory cytokines through NF-kappaB activation in meningitis, and that increased NF-kappaB activation in CSF cells indicate infectious meningitis rather than carcinomatous meningitis.