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Contemporary Clinical Epidemiology of Renal Cell Carcinoma: Insight From a Population Based Case-Control Study

2010; Lippincott Williams & Wilkins; Volume: 184; Issue: 6 Linguagem: Inglês

10.1016/j.juro.2010.08.018

1527-3792

David C. Miller, Julie J. Ruterbusch, Joanne S. Colt, Faith G. Davis, W. Marston Linehan, Wong‐Ho Chow, Kendra Schwartz,

Multiple and Secondary Primary Cancers

No AccessJournal of UrologyAdult Urology1 Dec 2010Contemporary Clinical Epidemiology of Renal Cell Carcinoma: Insight From a Population Based Case-Control Study David C. Miller, Julie Ruterbusch, Joanne S. Colt, Faith G. Davis, W. Marston Linehan, Wong-Ho Chow, and Kendra Schwartz David C. MillerDavid C. Miller Department of Urology, University of Michigan and Veterans Affairs Center for Clinical Management Research, Ann Arbor, Michigan , Julie RuterbuschJulie Ruterbusch Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan , Joanne S. ColtJoanne S. Colt Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland , Faith G. DavisFaith G. Davis Department of Epidemiology, University of Illinois at Chicago School of Public Health, Chicago, Illinois , W. Marston LinehanW. Marston Linehan Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland , Wong-Ho ChowWong-Ho Chow Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland , and Kendra SchwartzKendra Schwartz Department of Family Medicine and Public Health Sciences, Wayne State University School of Medicine, Detroit, Michigan View All Author Informationhttps://doi.org/10.1016/j.juro.2010.08.018AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: To clarify the contemporary clinical epidemiology of renal cell carcinoma we present trends in clinical presentation and treatment in patients enrolled in a population based case-control study. Materials and Methods: The National Cancer Institute performed a population based case-control study in metropolitan Detroit and Chicago from 2002 through 2007. In 1,136 patients with renal cell carcinoma who consented to an epidemiological interview and medical record review we ascertained detailed information on social and medical history, methods of renal cell carcinoma detection and diagnosis, cancer severity and treatment(s) received. From these data we assessed the demographic and cancer specific characteristics of study cases, and trends in clinical presentation, diagnosis and treatment. Results: Most patients with renal cell carcinoma had localized or regional tumors, including 52% with tumors 4 cm or less. The proportion of asymptomatic cases increased from 35% in 2002 to 50% in 2007 (p <0.001). Hypertension and diabetes were common in patients (58% and 17%, respectively) and 24% had at least 2 significant comorbid conditions at cancer diagnosis. While the use of laparoscopic surgery increased with time (p <0.001), fewer than 1/5 patients underwent nephron sparing surgery. Conclusions: The proportion of patients presenting with small, asymptomatic renal cell carcinoma continues to increase. Most of these cases are still treated with radical nephrectomy, although increasingly via a laparoscopic approach. Since most patients with small renal cell carcinomas have 1 or more renal function relevant comorbidities, there is an imperative to increase the use of nephron sparing surgery. References 1 : Rising incidence of renal cell cancer in the United States. JAMA1999; 281: 1628. Google Scholar 2 : Racial disparity in incidence patterns and outcome of kidney cancer. Urology2003; 62: 1012. Google Scholar 3 : Increasing incidence of all stages of kidney cancer in the last 2 decades in the United States: an analysis of surveillance, epidemiology and end results program data. J Urol2002; 167: 57. Link, Google Scholar 4 : Kidney cancer. J Urol2007; 177: 2006. 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Google Scholar © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byCorrea R, Louie A, Staehler M, Warner A, Gandhidasan S, Ponsky L, Ellis R, Kaplan I, Mahadevan A, Chu W, Swaminath A, Onishi H, Teh B, Lo S, Muacevic A and Siva S (2019) Stereotactic Radiotherapy as a Treatment Option for Renal Tumors in the Solitary Kidney: A Multicenter Analysis from the IROCKJournal of Urology, VOL. 201, NO. 6, (1097-1104), Online publication date: 1-Jun-2019.Klatte T, Shariat S and Remzi M (2018) Systematic Review and Meta-Analysis of Perioperative and Oncologic Outcomes of Laparoscopic Cryoablation Versus Laparoscopic Partial Nephrectomy for the Treatment of Small Renal TumorsJournal of Urology, VOL. 191, NO. 5, (1209-1217), Online publication date: 1-May-2014.Nepple K, Yang L, Grubb R and Strope S (2018) Population Based Analysis of the Increasing Incidence of Kidney Cancer in the United States: Evaluation of Age Specific Trends From 1975 to 2006Journal of Urology, VOL. 187, NO. 1, (32-38), Online publication date: 1-Jan-2012.Weight C, Atwell T, Fazzio R, Kim S, Kenny M, Lohse C, Boorjian S, Leibovich B and Thompson R (2018) A Multidisciplinary Evaluation of Inter-Reviewer Agreement of the Nephrometry Score and the Prediction of Long-Term OutcomesJournal of Urology, VOL. 186, NO. 4, (1223-1228), Online publication date: 1-Oct-2011.Ohno Y, Nakashima J, Ohori M, Hashimoto T, Iseki R, Hatano T and Tachibana M (2018) Impact of Tumor Size on Renal Function and Prediction of Renal Insufficiency After Radical Nephrectomy in Patients With Renal Cell CarcinomaJournal of Urology, VOL. 186, NO. 4, (1242-1246), Online publication date: 1-Oct-2011. Volume 184Issue 6December 2010Page: 2254-2258 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.KeywordscarcinomaAfrican Americansrenal cellEuropean continental ancestry groupkidneyepidemiologyMetricsAuthor Information David C. Miller Department of Urology, University of Michigan and Veterans Affairs Center for Clinical Management Research, Ann Arbor, Michigan More articles by this author Julie Ruterbusch Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan More articles by this author Joanne S. Colt Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland More articles by this author Faith G. Davis Department of Epidemiology, University of Illinois at Chicago School of Public Health, Chicago, Illinois More articles by this author W. Marston Linehan Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland More articles by this author Wong-Ho Chow Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland More articles by this author Kendra Schwartz Department of Family Medicine and Public Health Sciences, Wayne State University School of Medicine, Detroit, Michigan More articles by this author Expand All Advertisement PDF downloadLoading ...