A self-setting TTCP-DCPD apatite cement for release of vancomycin
1996; Wiley; Volume: 33; Issue: 3 Linguagem: Inglês
10.1002/(sici)1097-4636(199623)33
ISSN1097-4636
AutoresChiaki Hamanishi, Katsunori Kitamoto, Seisuke Tanaka, Makoto Otsuka, Yutaka Doi, Toshihiro Kitahashi,
Tópico(s)Dental materials and restorations
ResumoJournal of Biomedical Materials ResearchVolume 33, Issue 3 p. 139-143 Original Reports and Reviews A self-setting TTCP-DCPD apatite cement for release of vancomycin Chiaki Hamanishi, Corresponding Author Chiaki Hamanishi Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, JapanDepartment of Orthopaedic Surgery, Kinki University School of Medicine, Ohno-Higashi, Osaka-Sayama, Osaka 589, JapanSearch for more papers by this authorKatsunori Kitamoto, Katsunori Kitamoto Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, JapanSearch for more papers by this authorSeisuke Tanaka, Seisuke Tanaka Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, JapanSearch for more papers by this authorMakoto Otsuka, Makoto Otsuka Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Kobe, JapanSearch for more papers by this authorYutaka Doi, Yutaka Doi Department of Dental Material and Technology, School of Dentistry, Asahi University, Gifu, JapanSearch for more papers by this authorToshihiro Kitahashi, Toshihiro Kitahashi Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, JapanSearch for more papers by this author Chiaki Hamanishi, Corresponding Author Chiaki Hamanishi Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, JapanDepartment of Orthopaedic Surgery, Kinki University School of Medicine, Ohno-Higashi, Osaka-Sayama, Osaka 589, JapanSearch for more papers by this authorKatsunori Kitamoto, Katsunori Kitamoto Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, JapanSearch for more papers by this authorSeisuke Tanaka, Seisuke Tanaka Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, JapanSearch for more papers by this authorMakoto Otsuka, Makoto Otsuka Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Kobe, JapanSearch for more papers by this authorYutaka Doi, Yutaka Doi Department of Dental Material and Technology, School of Dentistry, Asahi University, Gifu, JapanSearch for more papers by this authorToshihiro Kitahashi, Toshihiro Kitahashi Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, JapanSearch for more papers by this author First published: Autumn(Fall) 1996 https://doi.org/10.1002/(SICI)1097-4636(199623)33:3 3.0.CO;2-RCitations: 74AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Vancomycin (VCM), a methiciline-cefem resistant Staphylococcus aureus (MRSA)-specific antibiotic, was incorporated in a self-setting tetracalcium phosphate (TTCP)-dicalcium phosphate dihydrate (DCPD) apatite cement that hardened isothermally into a hydroxyapatite (HAP) phase with crystallinity similar to that of host bone. Effective release of VCM into PBS lasted for 2 weeks from cements containing 1% VCM and for longer than 9 weeks from cements containing 5% VCM. The rate of release of VCM differed between cements with different crystallinities as well as between the two dissolution media, PBS and simulated body fluid. Mean concentration of VCM in the bone marrow tissue released from cements containing 5% VCM was 20 times the minimum inhibitory concentration 3 weeks after implantation in bone. Direct contact with new bone was observed with the cements containing 1% VCM. Slow delivery of VCM from a self-setting TTCP-DCPD apatite cement with low crystallinity could be used to treat MRSA osteomyelitis. © 1996 John Wiley & Sons, Inc. Citing Literature Volume33, Issue3Autumn(Fall) 1996Pages 139-143 RelatedInformation
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