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Mo1478 KI-67 Cytological Index Can Distinguish Low Grade From High Grade Pancreatic Neuroendocrine Tumors: a Comparative Cyto-Histological Study of 53 Cases

2014; Elsevier BV; Volume: 79; Issue: 5 Linguagem: Inglês

10.1016/j.gie.2014.02.655

1097-6779

Gabriele Carlinfante, Paola Baccarini, Paolo Cecinato, D. Berretti, Tiziana Cassetti, M. Cavina, Silvio Cavuto, Rita Conigliaro, Alessandro De Pellegrin, Luca Di Tommaso, Carlo Fabbri, Adele Fornelli, Andrea Frasoldati, Giorgio Gardini, Luisa Losi, Livia Macciò, Raffaele Manta, Nico Pagano, Romano Sassatelli, Silvia Serra, Lorenzo Camellini,

Lung Cancer Research Studies

The Ki-67 labeling index has been found to bear prognostic significance in gastrointestinal neuroendocrine tumours (NETs) and it was recently incorporated in NET histological grading. Nevertheless, a reliable preoperative determination of NET grading could be useful in clinical practice. The aim of this study is to compare the results of Ki-67 labeling index, as measured on cytological samples, obtained by endoscopic ultrasound fine needle aspiration (EUS-FNA), and on surgical specimens, after complete resection, of patients with pancreatic NETs (P-NETs). We also investigated whether diagnostic performances might be improved, using a 5% (instead of 2%) cut-off value for defining G2 tumors.