INFLUENCE OF SOME ANTI-INFLAMMATORY, ANTIPYRETIC AND ANALGESIC AGENTS ON URINARY ENZYME LEVEL IN RATS
1978; Japanese Society of Toxicological Sciences; Volume: 3; Issue: 1 Linguagem: Inglês
10.2131/jts.3.1
ISSN1880-3989
AutoresKaito Tsurumi, Akira Abe, Masakatsu Nozaki, Hajimè Fujimura,
Tópico(s)Pharmacology and Obesity Treatment
ResumoThe influence of single oral dose of anti-inflammatory, antipyretic and analgesic agents on urinary enzymes was investigated in rats as a indicator of nephrotoxic effect. Urinary LDH activity was significantly elevated by aspirin, ketophenylbutazone, aminopyrine, phenacetin and acetaminophen. These drugs increased also H/M ratio of LDH isoenzymes. Although other test drugs have no effect on LDH in urine phenylbutazone and indomethacin elevated GPT and Al-P, oxyphenbutazone did γ-GT and anthranilic acid derivatives did Al-P and γ-GT. Other drugs such as sodium salicylate, ibufenac, ibuprofen, bucolome, aminopropylone, sulfinpyrazone, benzydamine and mepirizole did not significantly influence any enzyme activities measured in urine.
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