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Neurochemical effects of chronic co-administration of ritanserin and haloperidol: comparison with clozapine effects

1990; Elsevier BV; Volume: 190; Issue: 3 Linguagem: Inglês

10.1016/0014-2999(90)94206-d

1879-0712

Jaakko Lappalainen, Jarmo Hietala, Markku Koulu, Erkka Syvälahli,

Schizophrenia research and treatment

The effects of chronic treatment with clozapine (20 mg/kg per day), ritanserin (0.5 mg/kg per day), haloperidol (0.5 mg/kg per day), or the combination of haloperidol and ritanserin, on dopamine (DA) and serotonin (5-HT) metabolism were studied. Chronic haloperidol treatment decreased DA metabolism in nucleus caudatus. Chronic ritanserin treatment failed to alter striatal or mesolimbic DA metabolism but decreased the concentrations of 5-HT and 5-hydroxyindoleacetic acid in the nucleus raphe dorsalis. The effects of chronic haloperidol were not altered by concomitant ritanserin administration. In comparison, chronic clozapine treatment affected neither DA nor 5-HT metabolism. These results show that the biochemical effects of chronic haloperidol treatment on the major ascending DA neurons cannot be modulated by concomitant 5-HT2 receptor blockade.