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Cryoglobulinemia and Immune-Mediated Glomerulonephritis in Association With Hairy Cell Leukemia

1985; Elsevier BV; Volume: 6; Issue: 3 Linguagem: Inglês

10.1016/s0272-6386(85)80024-x

1523-6838

Michael F. S. Douglas, Melvin M. Schwartz, Zeev Sharon,

Renal Diseases and Glomerulopathies

The nephrotic syndrome in association with hairy cell leukemia is typically seen in the setting of amyloidosis. This report describes a patient with the nephrotic syndrome and hairy cell leukemia in whom cryoglobulinemia and an immune-mediated glomerulonephritis were seen. While hairy cells have the capacity for immunoglobulin production, we were unable to demonstrate a teleological link between these cells and the renal lesion. In contrast, there is speculative evidence to suggest that indolent infections may have played a causative role in cryoglobulin production and the subsequent immune-mediated glomerulonephritis. The nephrotic syndrome in association with hairy cell leukemia is typically seen in the setting of amyloidosis. This report describes a patient with the nephrotic syndrome and hairy cell leukemia in whom cryoglobulinemia and an immune-mediated glomerulonephritis were seen. While hairy cells have the capacity for immunoglobulin production, we were unable to demonstrate a teleological link between these cells and the renal lesion. In contrast, there is speculative evidence to suggest that indolent infections may have played a causative role in cryoglobulin production and the subsequent immune-mediated glomerulonephritis.