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BIBTEX RIS

Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels

2014; Elsevier BV; Volume: 20; Linguagem: Inglês

10.1016/j.mito.2014.12.003

ISSN

1872-8278

Autores

Alejandro Ciocci Pardo, Gustavo Rinaldi, Susana M. Mosca,

Tópico(s)

Adipose Tissue and Metabolism

Resumo

The aim was to study the mitochondrial Ca2 + handling of mitochondria isolated from normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) hearts and to establish a possible correlation with systolic blood pressure (SBP). Mitochondrial swelling after Ca2 + addition, Ca2 +-retention capacity (CRC) by calcium green method, and membrane potential (ΔΨm) were assessed. SBP was 124 ± 1 (WKY) and 235 ± 6 mm Hg (SHR). CRC, Ca2 + response and ΔΨm were lower in SHR than WKY mitochondria. The conclusion is: the more depolarized state of SHR than WKY mitochondria results in an abnormal Ca2 + handling and this event is closely associated with the SBP.

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